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Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection wi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Straub, Tobias, Freudenberg, Marina A., Schleicher, Ulrike, Bogdan, Christian, Gasteiger, Georg, Pircher, Hanspeter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175863/
https://ncbi.nlm.nih.gov/pubmed/30297690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06609-z
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