Disease-associated short tandem repeats co-localize with chromatin domain boundaries

More than 25 inherited human disorders are caused by the unstable expansion of repetitive DNA sequences termed short tandem repeats (STRs). A fundamental unresolved question is why some STRs are susceptible to pathologic expansion, whereas thousands of repeat tracts across the human genome are relat...

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Publicado no:Cell
Main Authors: Sun, James H., Zhou, Linda, Emerson, Daniel J., Phyo, Sai, Titus, Katelyn R., Gong, Wanfeng, Gilgenast, Thomas G., Beagan, Jonathan A., Davidson, Beverly L., Tassone, Flora, Phillips-Cremins, Jennifer E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175607/
https://ncbi.nlm.nih.gov/pubmed/30173918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.005
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