Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP

Regulation of RNA polymerase II (Pol II) elongation is a critical step in gene regulation. Here, we report that U1 snRNP recognition and transcription pausing at stable nucleosomes are linked through premature polyadenylation signal (PAS) termination. By generating RNA exosome conditional deletion m...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Chiu, Anthony C., Suzuki, Hiroshi I., Wu, Xuebing, Mahat, Dig B., Kriz, Andrea J., Sharp, Phillip A.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175280/
https://ncbi.nlm.nih.gov/pubmed/29398447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.006
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