Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP

Regulation of RNA polymerase II (Pol II) elongation is a critical step in gene regulation. Here, we report that U1 snRNP recognition and transcription pausing at stable nucleosomes are linked through premature polyadenylation signal (PAS) termination. By generating RNA exosome conditional deletion m...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Chiu, Anthony C., Suzuki, Hiroshi I., Wu, Xuebing, Mahat, Dig B., Kriz, Andrea J., Sharp, Phillip A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175280/
https://ncbi.nlm.nih.gov/pubmed/29398447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.006
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