Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism increase Hcy-thiolactone, which causes protein damage by forming isopetide bonds with lysine residues, generating N-Hcy-protein. In the present work, we studied the prevalence and genetic determinants of keratin damage caused by ho...

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Publicat a:Int J Genomics
Autors principals: Borowczyk, Kamila, Wróblewski, Jacek, Suliburska, Joanna, Akahoshi, Noriyuki, Ishii, Isao, Jakubowski, Hieronim
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2018
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174792/
https://ncbi.nlm.nih.gov/pubmed/30345292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7570850
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