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Quantitative evaluation of tau PET tracers (18)F-THK5351 and (18)F-AV-1451 in Alzheimer’s disease with standardized uptake value peak-alignment (SUVP) normalization

PURPOSE: Off-target binding in the reference region is a challenge for recent tau tracers (18)F-AV-1451 and (18)F-THK5351. The conventional standardized uptake value ratio (SUVR) method relies on the average uptake from an unaffected tissue sample, and therefore is susceptible to biases from off-tar...

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Bibliografiske detaljer
Udgivet i:Eur J Nucl Med Mol Imaging
Main Authors: Chen, Jingyun, Li, Yi, Pirraglia, Elizabeth, Okamura, Nobuyuki, Rusinek, Henry, de Leon, Mony J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6174003/
https://ncbi.nlm.nih.gov/pubmed/29704038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-018-4040-1
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