Ankyrin Repeat Domain 1 Overexpression is Associated with Common Resistance to Afatinib and Osimertinib in EGFR-mutant Lung Cancer

Overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is critical in combating EGFR-mutant non-small cell lung cancer (NSCLC). We tried to construct a novel therapeutic strategy to conquer the resistance to second-and third-generation EGFR-TKIs in...

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Udgivet i:Sci Rep
Main Authors: Takahashi, Akiko, Seike, Masahiro, Chiba, Mika, Takahashi, Satoshi, Nakamichi, Shinji, Matsumoto, Masaru, Takeuchi, Susumu, Minegishi, Yuji, Noro, Rintaro, Kunugi, Shinobu, Kubota, Kaoru, Gemma, Akihiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173712/
https://ncbi.nlm.nih.gov/pubmed/30291293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33190-8
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