Overcoming drug-tolerant cancer cell subpopulations showing AXL activation and epithelial–mesenchymal transition is critical in conquering ALK-positive lung cancer

Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) induce a dramatic response in non–small cell lung cancer (NSCLC) patients with the ALK fusion gene. However, acquired resistance to ALK-TKIs remains an inevitable problem. In this study, we aimed to discover novel therapeutic targets t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nakamichi, Shinji, Seike, Masahiro, Miyanaga, Akihiko, Chiba, Mika, Zou, Fenfei, Takahashi, Akiko, Ishikawa, Arimi, Kunugi, Shinobu, Noro, Rintaro, Kubota, Kaoru, Gemma, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007478/
https://ncbi.nlm.nih.gov/pubmed/29930762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25531
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