A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors

PTSD is highly comorbid with cocaine use disorder (CUD), and cocaine users with PTSD + CUD are more resistant to treatment. Here we sought to develop a rat model of PTSD + CUD in order to identify the neurobiological changes underlying such comorbidity and screen potential medications for reducing c...

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Pubblicato in:Transl Psychiatry
Autori principali: Schwendt, Marek, Shallcross, John, Hadad, Natalie A., Namba, Mark D., Hiller, Helmut, Wu, Lizhen, Krause, Eric G., Knackstedt, Lori A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173705/
https://ncbi.nlm.nih.gov/pubmed/30291225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0265-9
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