Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold

This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound was carried out with groups diverse in their...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Bosak, Anita, Ramić, Alma, Šmidlehner, Tamara, Hrenar, Tomica, Primožič, Ines, Kovarik, Zrinka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173406/
https://ncbi.nlm.nih.gov/pubmed/30289893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205193
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