SSeCKS/Akap12 suppresses metastatic melanoma lung colonization by attenuating Src-mediated pre-metastatic niche crosstalk

SSeCKS/Gravin/AKAP12 (SSeCKS) controls metastasis-associated PKC and Src signaling through direct scaffolding activity. SSeCKS is downregulated in the metastases of many human cancer types, and its forced re-expression suppresses the metastatic behavior of prostate cancer cells. SSeCKS is also downr...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Muramatsu, Masashi, Akakura, Shin, Gao, Lingqiu, Peresie, Jennifer, Balderman, Benjamin, Gelman, Irwin H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173366/
https://ncbi.nlm.nih.gov/pubmed/30323895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26067
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