Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

Bosentan is well-known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic and metabolomic level. For this purpose, human hepatoma-derived HepaRG cells were exposed to a number of concentra...

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Pubblicato in:Arch Toxicol
Autori principali: Rodrigues, Robim M., Kollipara, Laxmikanth, Chaudhari, Umesh, Sachinidis, Agapios, Zahedi, René P., Sickmann, Albert, Kopp-Schneider, Annette, Jiang, Xiaoqi, Keun, Hector, Hengstler, Jan, Oorts, Marlies, Annaert, Pieter, Hoeben, Eef, Gijbels, Eva, De Kock, Joery, Vanhaecke, Tamara, Rogiers, Vera, Vinken, Mathieu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173297/
https://ncbi.nlm.nih.gov/pubmed/29761207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2214-z
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