A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress

In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer treatment strategy. Inhibitors targeting ULK1, an essential a...

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Publicado no:iScience
Main Authors: Martin, Katie R., Celano, Stephanie L., Solitro, Abigail R., Gunaydin, Hakan, Scott, Mark, O'Hagan, Ronan C., Shumway, Stuart D., Fuller, Peter, MacKeigan, Jeffrey P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172447/
https://ncbi.nlm.nih.gov/pubmed/30292171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.09.012
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