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Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock

Hemorrhagic shock depletes nicotinamide adenine dinucleotide (NAD) and causes metabolic derangements that, in severe cases, cannot be overcome, even after restoration of blood volume and pressure. However, current strategies to treat acute blood loss do not target cellular metabolism. We hypothesize...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Sims, Carrie A., Guan, Yuxia, Mukherjee, Sarmistha, Singh, Khushboo, Botolin, Paul, Davila, Antonio, Baur, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171817/
https://ncbi.nlm.nih.gov/pubmed/30185676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.120182
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