Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34(+) Hematopoietic Stem and Progenitor Cells

Genome-editing technologies are currently being translated to the clinic. However, cellular effects of the editing machinery have yet to be fully elucidated. Here, we performed global microarray-based gene expression measurements on human CD34(+) hematopoietic stem and progenitor cells that underwen...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Cromer, M. Kyle, Vaidyanathan, Sriram, Ryan, Daniel E., Curry, Bo, Lucas, Anne Bergstrom, Camarena, Joab, Kaushik, Milan, Hay, Sarah R., Martin, Renata M., Steinfeld, Israel, Bak, Rasmus O., Dever, Daniel P., Hendel, Ayal, Bruhn, Laurakay, Porteus, Matthew H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171165/
https://ncbi.nlm.nih.gov/pubmed/30005866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.06.002
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