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A1899, PK‐THPP, ML365, and Doxapram inhibit endogenous TASK channels and excite calcium signaling in carotid body type‐1 cells

Sensing of hypoxia and acidosis in arterial chemoreceptors is thought to be mediated through the inhibition of TASK and possibly other (e.g., BK(C) (a)) potassium channels which leads to membrane depolarization, voltage‐gated Ca‐entry, and neurosecretion. Here, we investigate the effects of pharmaco...

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Dades bibliogràfiques
Publicat a:Physiol Rep
Autors principals: O'Donohoe, Peadar B., Huskens, Nicky, Turner, Philip J., Pandit, Jaideep J., Buckler, Keith J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170881/
https://ncbi.nlm.nih.gov/pubmed/30284397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13876
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