A digital RNA signature of Circulating Tumor Cells predicting early therapeutic response in localized and metastatic breast cancer

The multiplicity of new therapies for breast cancer presents a challenge for treatment selection. We describe a 17-gene digital signature of breast circulating tumor cell (CTC)-derived transcripts enriched from blood, enabling high-sensitivity early monitoring of response. In a prospective cohort of...

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Bibliographic Details
Published in:Cancer Discov
Main Authors: Kwan, Tanya T., Bardia, Aditya, Spring, Laura M., Giobbie-Hurder, Anita, Kalinich, Mark, Dubash, Taronish, Sundaresan, Tilak, Hong, Xin, LiCausi, Joseph A., Ho, Uyen, Silva, Erin J., Wittner, Ben S., Sequist, Lecia V., Kapur, Ravi, Miyamoto, David T., Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170694/
https://ncbi.nlm.nih.gov/pubmed/30104333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0432
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