Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes

Recently, μ-opioid receptor (MOR), one of the well-known Gi-protein coupled receptors (Gi-GPCR), was reported to be highly expressed in the hippocampal astrocytes. However, the role of astrocytic MOR has not been investigated. Here we report that activation of astrocytic MOR by [D-Ala(2),N-MePhe(4),...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Woo, Dong Ho, Bae, Jin Young, Nam, Min-Ho, An, Heeyoung, Ju, Yeon Ha, Won, Joungha, Choi, Jae Hyouk, Hwang, Eun Mi, Han, Kyung-Seok, Bae, Yong Chul, Lee, C. Justin
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170663/
https://ncbi.nlm.nih.gov/pubmed/30319359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00319
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