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STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH

Dysregulated intracellular pH is emerging as a hallmark of cancer. In spite of their acidic environment and increased acid production, cancer cells maintain alkaline intracellular pH that promotes cancer progression by inhibiting apoptosis and increasing glycolysis, cell growth, migration, and invas...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Liu, Bin, Palmfeldt, Johan, Lin, Lin, Colaço, Alexandria, Clemmensen, Knut K. B., Huang, Jinrong, Xu, Fengping, Liu, Xin, Maeda, Kenji, Luo, Yonglun, Jäättelä, Marja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170402/
https://ncbi.nlm.nih.gov/pubmed/30127373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0080-0
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