Fusion surface structure, function, and dynamics of gamete fusogen HAP2

HAP2 is a class II gamete fusogen in many eukaryotic kingdoms. A crystal structure of Chlamydomonas HAP2 shows a trimeric fusion state. Domains D1, D2.1 and D2.2 line the 3-fold axis; D3 and a stem pack against the outer surface. Surprisingly, hydrogen-deuterium exchange shows that surfaces of D1, D...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Feng, Juan, Dong, Xianchi, Pinello, Jennifer, Zhang, Jun, Lu, Chafen, Iacob, Roxana E, Engen, John R, Snell, William J, Springer, Timothy A
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2018
Teme:
Biochemistry and Chemical Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170185/
https://ncbi.nlm.nih.gov/pubmed/30281023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39772
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