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Structural features and domain movements controlling substrate binding and cofactor specificity in class II HMG-CoA reductase
The key mevalonate pathway enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) uses the cofactor NAD(P)H to reduce HMG-CoA to mevalonate in the production of countless metabolites and natural products. Although HMGR inhibition by statin drugs is well understood, several mechanist...
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| Publicado en: | Biochemistry |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6170158/ https://ncbi.nlm.nih.gov/pubmed/29224355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00999 |
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