Calcium-Dependent Src Phosphorylation and Reactive Oxygen Species Generation Are Implicated in the Activation of Human Platelet Induced by Thromboxane A2 Analogs

The thromboxane (TX) A(2) elicits TP-dependent different platelet responses. Low amounts activate Src kinases and the Rho–Rho kinase pathway independently of integrin α(IIb)β(3) and ADP secretion and synergize with epinephrine to induce aggregation. Aim of the present study was to investigate the ro...

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Udgivet i:Front Pharmacol
Main Authors: Minuz, Pietro, Meneguzzi, Alessandra, Fumagalli, Laura, Degan, Maurizio, Calabria, Stefano, Ferraro, Roberta, Ricci, Marco, Veneri, Dino, Berton, Giorgio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169403/
https://ncbi.nlm.nih.gov/pubmed/30319416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01081
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