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Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment
The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers for decades...
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| 發表在: | mBio |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168864/ https://ncbi.nlm.nih.gov/pubmed/30279281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01211-18 |
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