Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

The protein tyrosine phosphatase PTPN11 is implicated in the pathogenesis of juvenile myelomonocytic leukemia (JMML), acute myeloid leukemia (AML), and other malignancies. Activating mutations in PTPN11 increase downstream proliferative signaling and cell survival. We investigated the signaling upst...

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Bibliografski detalji
Izdano u:Sci Signal
Glavni autori: Jenkins, Chelsea, Luty, Samuel B., Maxson, Julia E., Eide, Christopher A., Abel, Melissa L., Togiai, Corinne, Nemecek, Eneida R., Bottomly, Daniel, McWeeney, Shannon K., Wilmot, Beth, Loriaux, Marc, Chang, Bill H., Tyner, Jeffrey W.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168748/
https://ncbi.nlm.nih.gov/pubmed/30018082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao5617
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