Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

The protein tyrosine phosphatase PTPN11 is implicated in the pathogenesis of juvenile myelomonocytic leukemia (JMML), acute myeloid leukemia (AML), and other malignancies. Activating mutations in PTPN11 increase downstream proliferative signaling and cell survival. We investigated the signaling upst...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Jenkins, Chelsea, Luty, Samuel B., Maxson, Julia E., Eide, Christopher A., Abel, Melissa L., Togiai, Corinne, Nemecek, Eneida R., Bottomly, Daniel, McWeeney, Shannon K., Wilmot, Beth, Loriaux, Marc, Chang, Bill H., Tyner, Jeffrey W.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168748/
https://ncbi.nlm.nih.gov/pubmed/30018082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao5617
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