Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

The protein tyrosine phosphatase PTPN11 is implicated in the pathogenesis of juvenile myelomonocytic leukemia (JMML), acute myeloid leukemia (AML), and other malignancies. Activating mutations in PTPN11 increase downstream proliferative signaling and cell survival. We investigated the signaling upst...

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Détails bibliographiques
Publié dans:Sci Signal
Auteurs principaux: Jenkins, Chelsea, Luty, Samuel B., Maxson, Julia E., Eide, Christopher A., Abel, Melissa L., Togiai, Corinne, Nemecek, Eneida R., Bottomly, Daniel, McWeeney, Shannon K., Wilmot, Beth, Loriaux, Marc, Chang, Bill H., Tyner, Jeffrey W.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168748/
https://ncbi.nlm.nih.gov/pubmed/30018082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao5617
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