Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

The protein tyrosine phosphatase PTPN11 is implicated in the pathogenesis of juvenile myelomonocytic leukemia (JMML), acute myeloid leukemia (AML), and other malignancies. Activating mutations in PTPN11 increase downstream proliferative signaling and cell survival. We investigated the signaling upst...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Jenkins, Chelsea, Luty, Samuel B., Maxson, Julia E., Eide, Christopher A., Abel, Melissa L., Togiai, Corinne, Nemecek, Eneida R., Bottomly, Daniel, McWeeney, Shannon K., Wilmot, Beth, Loriaux, Marc, Chang, Bill H., Tyner, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168748/
https://ncbi.nlm.nih.gov/pubmed/30018082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao5617
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