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Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient

Performing drug screening of tissue derived from cancer patient biopsies using physiologically relevant 3D tumour models presents challenges due to the limited amount of available cell material. Here, we present a microfluidic platform that enables drug screening of cancer cell-enriched multicellula...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Mulholland, Theresa, McAllister, Milly, Patek, Samantha, Flint, David, Underwood, Mark, Sim, Alexander, Edwards, Joanne, Zagnoni, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168499/
https://ncbi.nlm.nih.gov/pubmed/30279484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33055-0
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