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Drug screening of biopsy-derived spheroids using a self-generated microfluidic concentration gradient

Performing drug screening of tissue derived from cancer patient biopsies using physiologically relevant 3D tumour models presents challenges due to the limited amount of available cell material. Here, we present a microfluidic platform that enables drug screening of cancer cell-enriched multicellula...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mulholland, Theresa, McAllister, Milly, Patek, Samantha, Flint, David, Underwood, Mark, Sim, Alexander, Edwards, Joanne, Zagnoni, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168499/
https://ncbi.nlm.nih.gov/pubmed/30279484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33055-0
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