Histone methyltransferase KMT2D sustains prostate carcinogenesis and metastasis via epigenetically activating LIFR and KLF4

Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer (PCa). The histone methyltransferase KMT2D, a frequently aberrant epigenetic modifier in various tumors, has an undefined role in PCa. Moreover, little is known regarding KMT2D’s mutation in Chinese patients or i...

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Pubblicato in:Oncogene
Autori principali: Lv, Shidong, Ji, Liyan, Chen, Bin, Liu, Shuqiang, Lei, Chengyong, Liu, Xi, Qi, Xiaoxiao, Wang, Ying, Lai-Han Leung, Elaine, Wang, Hongyi, Zhang, Lin, Yu, Xiaoming, Liu, Zhongqiu, Wei, Qiang, Lu, Linlin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168472/
https://ncbi.nlm.nih.gov/pubmed/29269867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0026-x
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