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Low Molecular Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies
Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (CDK2), is central to the initiation of DNA replication at the G(1)/S-checkpoint. Tight temporal control of cyclin E is essential to the coordination of cell cycle processes and the maintenance of genome integrity. Overexpression of cyclin...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168358/ https://ncbi.nlm.nih.gov/pubmed/30194068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1235 |
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