Cdt1 stabilizes kinetochore–microtubule attachments via an Aurora B kinase–dependent mechanism

Robust kinetochore–microtubule (kMT) attachment is critical for accurate chromosome segregation. G2/M-specific depletion of human Cdt1 that localizes to kinetochores in an Ndc80 complex–dependent manner leads to abnormal kMT attachments and mitotic arrest. This indicates an independent mitotic role...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Agarwal, Shivangi, Smith, Kyle Paul, Zhou, Yizhuo, Suzuki, Aussie, McKenney, Richard J., Varma, Dileep
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168275/
https://ncbi.nlm.nih.gov/pubmed/30154187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201705127
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