Mechanotransduction by Pcdh15 relies on a novel cis-dimeric architecture

The tip link, a filament formed by protocadherin 15 (Pcdh15) and cadherin 23, conveys mechanical force from sound waves and head movement to open hair-cell mechanotransduction channels. Tip-link cadherins are thought to have acquired structural features critical for their role in mechanotransduction...

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Publicado no:Neuron
Main Authors: Dionne, Gilman, Qiu, Xufeng, Rapp, Micah, Liang, Xiaoping, Zhao, Bo, Peng, Guihong, Katsamba, Phinikoula S., Ahlsen, Goran, Rubinstein, Rotem, Potter, Clinton S., Carragher, Bridget, Honig, Barry, Müller, Ulrich, Shapiro, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168201/
https://ncbi.nlm.nih.gov/pubmed/30057206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.07.006
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