BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

BACKGROUND: Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This study aimed to elucidate the function of BHLHE40 in the metastatic process of brea...

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Publicado en:Breast Cancer Res
Autores principales: Sethuraman, Aarti, Brown, Martin, Krutilina, Raya, Wu, Zhao-Hui, Seagroves, Tiffany N., Pfeffer, Lawrence M., Fan, Meiyun
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167787/
https://ncbi.nlm.nih.gov/pubmed/30285805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-1046-3
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