Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection

The lung is a critical prophylaxis target for clinically important infectious agents, including human respiratory syncytial virus (RSV) and influenza. Here, we develop a modular, synthetic mRNA-based approach to express neutralizing antibodies directly in the lung via aerosol, to prevent RSV infecti...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tiwari, Pooja Munnilal, Vanover, Daryll, Lindsay, Kevin E., Bawage, Swapnil Subhash, Kirschman, Jonathan L., Bhosle, Sushma, Lifland, Aaron W., Zurla, Chiara, Santangelo, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167369/
https://ncbi.nlm.nih.gov/pubmed/30275522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06508-3
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