Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells

The use of synthetic messenger ribonucleic acid (mRNA) to express specific proteins is a highly promising therapeutic and vaccine approach that avoids many safety issues associated with viral or DNA-based systems. However, in order to optimize mRNA designs and delivery, technology advancements are r...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kirschman, Jonathan L., Bhosle, Sushma, Vanover, Daryll, Blanchard, Emmeline L., Loomis, Kristin H., Zurla, Chiara, Murray, Kathryn, Lam, Blaine C., Santangelo, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499550/
https://ncbi.nlm.nih.gov/pubmed/28449134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx290
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