Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells

The use of synthetic messenger ribonucleic acid (mRNA) to express specific proteins is a highly promising therapeutic and vaccine approach that avoids many safety issues associated with viral or DNA-based systems. However, in order to optimize mRNA designs and delivery, technology advancements are r...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Kirschman, Jonathan L., Bhosle, Sushma, Vanover, Daryll, Blanchard, Emmeline L., Loomis, Kristin H., Zurla, Chiara, Murray, Kathryn, Lam, Blaine C., Santangelo, Philip J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499550/
https://ncbi.nlm.nih.gov/pubmed/28449134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx290
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