Outward open conformation of a Major Facilitator Superfamily multidrug/H(+) antiporter provides insights into switching mechanism

Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major facilitator superfamily (MFS) drug/H(+) antiporter MdfA from Escherichia coli i...

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Publicado en:Nat Commun
Main Authors: Nagarathinam, Kumar, Nakada-Nakura, Yoshiko, Parthier, Christoph, Terada, Tohru, Juge, Narinobu, Jaenecke, Frank, Liu, Kehong, Hotta, Yunhon, Miyaji, Takaaki, Omote, Hiroshi, Iwata, So, Nomura, Norimichi, Stubbs, Milton T., Tanabe, Mikio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167325/
https://ncbi.nlm.nih.gov/pubmed/30275448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06306-x
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