Plasmodium falciparum chloroquine resistance transporter is a H(+)-coupled polyspecific nutrient and drug exporter

Extrusion of chloroquine (CQ) from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter (PfCRT) is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ remain...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Juge, Narinobu, Moriyama, Sawako, Miyaji, Takaaki, Kawakami, Mamiyo, Iwai, Haruka, Fukui, Tomoya, Nelson, Nathan, Omote, Hiroshi, Moriyama, Yoshinori
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371956/
https://ncbi.nlm.nih.gov/pubmed/25733858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417102112
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