Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

Murine norovirus (MNoV) is closely related to human norovirus (HNoV), an infectious agent responsible for acute gastroenteritis worldwide. Here we report the X-ray crystal structure of the dimeric MNoV VP1 protruding (P) domain in complex with its cellular receptor CD300lf. CD300lf binds the P domai...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Nelson, Christopher A., Wilen, Craig B., Dai, Ya-Nan, Orchard, Robert C., Kim, Arthur S., Stegeman, Roderick A., Hsieh, Leon L., Smith, Thomas J., Virgin, Herbert W., Fremont, Daved H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166816/
https://ncbi.nlm.nih.gov/pubmed/30194229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805797115
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