Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease

The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown. Here, we studied how anti-CD20 treatment influenc...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Häusler, Darius, Häusser-Kinzel, Silke, Feldmann, Linda, Torke, Sebastian, Lepennetier, Gildas, Bernard, Claude C. A., Zamvil, Scott S., Brück, Wolfgang, Lehmann-Horn, Klaus, Weber, Martin S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166805/
https://ncbi.nlm.nih.gov/pubmed/30194232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810470115
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