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A Processive Protein Chimera Introduces Mutations Across Defined DNA Regions In Vivo
Laboratory time scale evolution in vivo relies on the generation of large, mutationally diverse gene libraries to rapidly explore biomolecule sequence landscapes. Traditional global mutagenesis methods are problematic because they introduce many off-target mutations that are often lethal and can eng...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166643/ https://ncbi.nlm.nih.gov/pubmed/29991261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04001 |
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