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A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

BACKGROUND: Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and inflammation. Common asthma therapeutics up-re...

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Publicat a:Allergy Asthma Clin Immunol
Autors principals: George, Tresa, Chakraborty, Mainak, Giembycz, Mark A., Newton, Robert
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166284/
https://ncbi.nlm.nih.gov/pubmed/30305828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13223-018-0266-5
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