β(2)-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

In asthma and chronic obstructive pulmonary disease, activation of G(q)-protein–coupled receptors causes bronchoconstriction. In each case, the management of moderate-to-severe disease uses inhaled corticosteroid (glucocorticoid)/long-acting β(2)-adrenoceptor agonist (LABA) combination therapies, wh...

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Bibliographische Detailangaben
Hauptverfasser: Holden, Neil S., Bell, Matthew J., Rider, Christopher F., King, Elizabeth M., Gaunt, David D., Leigh, Richard, Johnson, Malcolm, Siderovski, David P., Heximer, Scott P., Giembycz, Mark A., Newton, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241812/
https://ncbi.nlm.nih.gov/pubmed/22080612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110226108
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