UBXN2A enhances CHIP‐mediated proteasomal degradation of oncoprotein mortalin‐2 in cancer cells

Overexpression of oncoproteins is a major cause of treatment failure using current chemotherapeutic drugs. Drug‐induced degradation of oncoproteins is feasible and can improve clinical outcomes in diverse types of cancers. Mortalin‐2 (mot‐2) is a dominant oncoprotein in several tumors, including col...

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Pubblicato in:Mol Oncol
Autori principali: Sane, Sanam, Hafner, Andre, Srinivasan, Rekha, Masood, Daniall, Slunecka, John l., Noldner, Collin J., Hanson, Alex D., Kruisselbrink, Taylor, Wang, Xuejun, Wang, Yiyang, Yin, Jun, Rezvani, Khosrow
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166003/
https://ncbi.nlm.nih.gov/pubmed/30107089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12372
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