Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation

AMP-activated protein kinase (AMPK) is frequently reported to phosphorylate Ser1177 of the endothelial nitric-oxide synthase (eNOS), and therefore, is linked with a relaxing effect. However, previous studies failed to consistently demonstrate a major role for AMPK on eNOS-dependent relaxation. As AM...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Zippel, Nina, Loot, Annemarieke E., Stingl, Heike, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Fisslthaler, Beate
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165563/
https://ncbi.nlm.nih.gov/pubmed/30217073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092753
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