Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models

Background: Oxidant stress plays a key role in the development of chronic kidney disease (CKD). Experimental CKD leads to accumulation of uremic toxins (UT) in the circulation resulting in increased ROS production, which in turn, is known to activate the Na/K-ATPase/ROS amplification loop. Studies i...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bartlett, David E., Miller, Richard B., Thiesfeldt, Scott, Lakhani, Hari Vishal, Khanal, Tilak, D. Pratt, Rebecca, Cottrill, Cameron L., Klug, Rebecca L., Adkins, Nathaniel Seth, Bown, Paul C., Nease, D. Blaine, Shapiro, Joseph I., Sodhi, Komal
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6164729/
https://ncbi.nlm.nih.gov/pubmed/30201874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092685
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