Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy

BACKGROUND: Oxidative stress in adipocyte plays a central role in the pathogenesis of obesity as well as in the associated cardiovascular complications. The putative uremic toxin indoxyl sulfate induces oxidative stress and dramatically alters adipocyte phenotype in vitro. Mice that have undergone p...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Sodhi, Komal, Wang, Xiaoliang, Chaudhry, Muhammad Aslam, Lakhani, Hari Vishal, Zehra, Mishghan, Pratt, Rebecca, Nawab, Athar, Cottrill, Cameron L., Snoad, Brian, Bai, Fang, Denvir, James, Liu, Jiang, Sanabria, Juan R., Xie, Zijian, Abraham, Nader G., Shapiro, Joseph I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460907/
https://ncbi.nlm.nih.gov/pubmed/32587074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019101070
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