The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers that can translocate to the cell nucleus where...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Arora, Loukik, Kumar, Alan Prem, Arfuso, Frank, Chng, Wee Joo, Sethi, Gautam
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162647/
https://ncbi.nlm.nih.gov/pubmed/30217007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10090327
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