Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair

DNA repair systems are abnormally active in most hepatocellular carcinoma (HCC) cells due to accumulated mutations, resulting in elevated DNA repair capacity and resistance to chemotherapy and radiotherapy. Thus, targeting DNA repair mechanisms is a common treatment approach in HCC to sensitize canc...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Chen, Chin-Chuan, Chen, Chi-Yuan, Wang, Shu-Huei, Yeh, Chau-Ting, Su, Shih-Chi, Ueng, Shir-Hwa, Chuang, Wen-Yu, Hsueh, Chuen, Wang, Tong-Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162454/
https://ncbi.nlm.nih.gov/pubmed/30201872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10090320
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