Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair

DNA repair systems are abnormally active in most hepatocellular carcinoma (HCC) cells due to accumulated mutations, resulting in elevated DNA repair capacity and resistance to chemotherapy and radiotherapy. Thus, targeting DNA repair mechanisms is a common treatment approach in HCC to sensitize canc...

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Detalhes bibliográficos
Main Authors: Chin-Chuan Chen, Chi-Yuan Chen, Shu-Huei Wang, Chau-Ting Yeh, Shih-Chi Su, Shir-Hwa Ueng, Wen-Yu Chuang, Chuen Hsueh, Tong-Hong Wang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-09-01
Colecção:Cancers
Assuntos:
melatonin
hepatocellular carcinoma
DNA repair
lncRNA-RAD51-AS1
RAD51
Acesso em linha:http://www.mdpi.com/2072-6694/10/9/320
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