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A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR
Our meagre understanding of CFTR misfolding and its reversal by small-molecule correctors hampers the development of mechanism-based therapies of cystic fibrosis. Here we exploit a helical-hairpin construct—the simplest proxy of membrane-protein tertiary contacts—containing CFTR’s transmembrane heli...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6162264/ https://ncbi.nlm.nih.gov/pubmed/30302398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0153-0 |
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