Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways, through which they regulate innate immunity and inflammation. Evidence exists that IRAKs play key roles in the pathoph...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Singer, Jack W., Fleischman, Angela, Al-Fayoumi, Suliman, Mascarenhas, John O., Yu, Qiang, Agarwal, Anupriya
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161786/
https://ncbi.nlm.nih.gov/pubmed/30279971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26058
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