Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants

Heteromers of Kv7.2/Kv7.3 subunits constitute the main substrate of the neuronal M-current that limits neuronal hyper-excitability and firing frequency. Calmodulin (CaM) binding is essential for surface expression of Kv7 channels, and disruption of this interaction leads to diseases ranging from mil...

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Detalhes bibliográficos
Publicado no:Channels (Austin)
Main Authors: Alaimo, Alessandro, Etxeberria, Ainhoa, Gómez-Posada, Juan Camilo, Gomis-Perez, Carolina, Fernández-Orth, Juncal, Malo, Covadonga, Villarroel, Alvaro
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161613/
https://ncbi.nlm.nih.gov/pubmed/30126342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2018.1511512
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